Author information Article notes Copyright and License information Disclaimer. Vascular dysfunction not only affects the small arteries of the penis, but the larger coronary arteries of the heart too. In contrast, L-citrulline escapes intestinal or liver metabolism, and enters the kidneys where it is rapidly converted into L-arginine.
With a mean age of See the Deals. Aim We aimed to investigate the efficacy of combination therapy of L-citrulline and transresveratrol in patients with ED despite their use of PDE5i.
It is interesting to note that there are quite a few methods for measuring penile hardness. All patients reporting an erection hardness score improvement from 3 to 4 were highly satisfied. A P value less than. McCabe M. Events near me Oct. The data clearly showed that this supplementation can salvage the ED patient who fails treatment solely with PDE5i.
Discussion We investigated the efficacy of oral L-citrulline and transresveratrol supplementation in improving erection in patients with ED. We have no follow-up data on these patients following their completion of the study. The NO Pathway. Clinical Pearl: L-citrulline may be of great benefit for your female postmenopausal patients as well.
References available upon request.
We speculated that they may have been disappointed with the effect of the placebo used in group B. Iodine: the Next Vitamin D? Because the participants had moderate to severe ED, monotherapy with L-citrulline was thought to be insufficient compared with the findings in a previous study.
Urol J. The exclusion criteria were severe cardiovascular disease, recent cerebrovascular accidents, renal or hepatic insufficiency, psychiatric or severe neurologic disorders, untreated endocrine disease, previous radical prostatectomy, significant penile deformity, and previous or current treatment of ED.
Men taking L-citrulline revealed that the frequency of sexual intercourse was significantly increased compared with baseline.